I like to see some actual numbers on that. Because I consider LBJ a 'big guy'. He is 6"9 and 260 but virtually never has injury problems. Oden on the other hand got destroyed by injuries. Shaq only played 1 year of college and played from 19, logging huge minutes. He had a very long and productive career and was one of the heaviest centres to ever play. I would argue it depends more on conditioning and the nature of their bodies. Some can take it, others just cant.